Alpha-1-Antitrypsin

Alternate Name: A1 Antitrypsin Serum

  | Alpha1-Protease Inhibitor; Acute Phase Proteins

SAL Code:

501

CPT:

82103

Loinc:

1825-9

Turn Around Time:

1-2 days

Setup:

Daily

Units:

mg/dL

Department:

Special Chemistry

Methodology:

Immunologic

Specimen Requirements:

Primary Tube:

SST

Primary Substance:

Serum

Alternate Sample Info:

Lavender-top (EDTA) tube, or green-top (heparin) tube

Temperature

Period

Stable Ambient:

14 days

Stable Fridge:

14 days

Stable Frozen:

14 days

Rejection Criteria:

Chylous serum

Clinical Info:

Detection of hereditary decreases in the production of a1-antitrypsin (a1AT). Decreased or nearly absent levels of a1AT can be a factor in chronic obstructive lung disease and liver disease. An increased prevalence of non-MM phenotypes is found with cryptogenic cirrhosis and with CAH. Cirrhosis in a child should raise consideration of a1AT deficiency or Wilson's disease. Diagnosis of inflammatory states, if elevated (eg, rheumatoid arthritis, bacterial infection, vasculitis, neoplasia).

Additional Information:

Should be run when a1-globulin in serum protein electrophoresis is low or when two bands are seen in the a1-region. Heterozygous patients exhibit AAT levels which are commonly about 60% of normal. Homozygous recessive a1AT patients exhibit levels at about 10% of normal. Phenotyping is desirable on patients with low values and on all patients being worked up for AAT-deficient liver disease. Most pathologic is homozygous state ZZ. An M null genotype will have phenotype as MM but low serum level. AAT is one of the alpha-globulins, which together are called “acute phase reactants.” These rise rapidly, but nonspecifically, in response to inflammatory insults.

Contraindications: If CRP is positive, retest a1AT in 10-14 days.

Sample Collection:

Overnight fasting is preferred. Collect patient samples using standard phlebotomy techniques. Click here for additional collection instructions.

Test Information:

Components: