21-Hydroxylase Antibodies

Alternate Name: 21_hydroxylase_LC

  | Adrenal 21-Hydroxylase Autoantibodies

SAL Code:

7637

CPT:

83516

Loinc:

17781-6

Department:

Diagnostic Immunology

Methodology:

Enzyme-linked immunosorbent assay (ELISA)

Specimen Requirements:

Primary Tube:

SST

Primary Substance:

Serum

Alternate Sample Info:

Red Top Serum (No Gel)

Temperature

Period

Stable Fridge:

14 days

Stable Frozen:

2 years

Rejection Criteria:

Gross hemolysis; lipemia; improper labeling

Clinical Info:

Addison's disease (chronic primary adrenal insufficiency) is commonly caused by autoimmune destruction of the adrenal cortex and is characterized by the presence of adrenal cortex autoantibodies in the serum. It can occur sporadically or in combination with other autoimmune endocrine diseases that together comprise Type I or Type II autoimmune polyglandular syndrome. The microsomal autoantigen, steroid 21-hydroxylase enzyme, has been shown to be the primary autoantigen associated with autoimmune Addison's disease. Measurement of 21-hydroxylase autoantibodies aids in diagnosis and management of patients with adrenal insufficiency.

Sample Collection:

Collect patient samples using standard phlebotomy techniques. Click here for additional collection instructions.
Separate serum from cells within one hour. Transfer to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Test Information:

Components: