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14.3.3 ETA, Rheum. Arthritis

Alternate Name: 14.3.3n Protein ETA

  | Augurex

SAL Code:

8943

CPT:

83520

Loinc:

75880-5

Turn Around Time:

6-12 days

Units:

ng/mL

Department:

Diagnostic Immunology

Performing Laboratory:

LabCorp of America

Methodology:

Enzyme-linked immunosorbent assay (ELISA)

Specimen Requirements:

Primary Tube:

SST

Primary Substance:

Serum (FRZN)

Alternate Sample Info:

Red Top tube serum (no Gel)

Temperature

Period

Stable Fridge:

3 days

Stable Frozen:

7 days

Rejection Criteria:

Gross hemolysis; lipemia; improper labeling

Clinical Info:

14-3-3 eta protein is a joint-derived, proinflammatory mediator that is implicated in the joint erosion process and pathogenesis of RA. Serum 14-3-3 eta is elevated in both early and established RA.

Additional Information:

14-3-3 eta is highly specific for RA. Serum 14-3-3 eta may be especially helpful in identifying patients with early RA where it provides a 15% incremental benefit to the diagnostic sensitivity of markers, Rheumatoid Arthritis (RA) Factor and Cyclic Citrullinated Peptide (CCP) Antibodies. Positive serum 14-3-3 eta levels are associated with higher rates of joint damage as measured by radiographic assessments (Sharp/van der Heijde Score).

Sample Collection:

Collect patient samples using standard phlebotomy techniques. Click here for additional collection instructions.
Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transfer tube.

Test Limitations:

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Specimen Handling Instructions:

Frozen transport is preferred.

Test Information:

Components:

Brooklyn Navy Yard
Building 292, Suite 416
63 Flushing Avenue
Brooklyn, NY 11205

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